Acetic Anhydride → HCID 86665959, compound

HRID 1024777Notes

Reaction equation

HRID 1024777 reaction equation
[C:1]([O:5][C:6](=[O:45])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[C:20]([C:22]([N:24]3[CH:33]4[CH:28]([CH2:29][CH2:30][CH2:31][CH2:32]4)[CH2:27][CH2:26][CH2:25]3)=[O:23])[CH:19]=[C:18]([O:34][C:35]3[CH:40]=[CH:39][C:38]([C:41](=[NH:44])[NH:42][OH:43])=[CH:37][CH:36]=3)[CH:17]=2)=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[C:46](OC(=O)C)(=[O:48])[CH3:47]>>[C:1]([O:5][C:6](=[O:45])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[C:20]([C:22]([N:24]3[CH:33]4[CH:28]([CH2:29][CH2:30][CH2:31][CH2:32]4)[CH2:27][CH2:26][CH2:25]3)=[O:23])[CH:19]=[C:18]([O:34][C:35]3[CH:36]=[CH:37][C:38]([C:41](=[NH:44])[N:42]([OH:43])[C:46](=[O:48])[CH3:47])=[CH:39][CH:40]=3)[CH:17]=2)=[CH:11][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178453089HCID 178453089, compound

Product 1

HCID 86665959HCID 86665959, compound

Procedure

{4-[3-[4-(N-Hydroxycarbamimidoyl)phenoxy]-5-(octahydroquinoline-1-carbonyl)-phenoxyl]benzyl}carbamic acid tert-butyl ester, 1.4 g (2.28 mmol) was acetylated with 0.26 g (2.5 mmol) of acetic anhydride using the procedure of Example 2(e) to afford 1.04 g of the required product. Percentage purity (LCMS): 36.1%, (M+1)=654.3+1.

Sources & evidence

ORD record
ord-948673ed05da4e5d8d3c36883105b7e7
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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