反应详情

To a solution of 4,6-Dichloro-2-[(2,3-difluorobenzyl)thio]pyrimidine (0.50 g) in ethanol (5 mL) was added 60% sodium hydride (72 mg) and the reaction mixture was stirred at ambient temperature for 6 h. The mixture was diluted with H2O and extracted with EtOAc (×2). The combined organic layers were dried (MgSO4), filtered and evaporated to give the subtitle compound as a clear, colourless oil. Yield: 0.53 g

1. extractionextracted with EtOAc (×2)
2. dry with materialThe combined organic layers were dried (MgSO4)
3. filtrationfiltered
4. customevaporated