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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1024896Generated: October 28, 2026

1-methyl-1H-imidazole-4-sulfonamide → N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-methoxypyrimidin-4-yl)-1-methyl-1H-imidazole-4-sulfonamide

https://huagongshe.com/reaction/1024896

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-methyl-1H-imidazole-4-sulfonamideHCID 2736885—
Reactant4-Chloro-2-([(2,3-difluorophenyl)methyl]thio]-6-methoxypyrimidineHCID 86619877—
ProductN-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-methoxypyrimidin-4-yl)-1-methyl-1H-imidazole-4-sulfonamideHCID 11568103—

Reaction Steps

The title compound was prepared from 1-methyl-1H-imidazole-4-sulfonamide (0.19 g) and 4-Chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-methoxypyrimidine (the product of Example 35, step i) (0.25 g) according to the procedure outlined in Example 1, step iv). The crude material was purified by column chromatography using EtOAc/isohexane (2:8) as eluent. Yield: 0.11 g.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08722883B2
Source datasetuspto-grants-2014_05
ORD IDord-8890992ef14b4be589a462ae0af159b5
Source noteuspto-grants-2014_05