反应详情

A solution of N-{5-[(tert-butylamino)sulfonyl]-4-methyl-1,3-thiazol-2-yl}acetamide (1.1 g) in TFA (10 ml) was stirred at room temperature for 3d. The mixture was evaporated, redissolved in TFA (10 ml) and stirred for a further 1 d. On evaporation the resulting oil was azeotroped with DCM (×2) and triturated with Et2O to give the subtitle compound as a beige solid. Yield 0.7 g.

1. customThe mixture was evaporated
2. dissolutionredissolved in TFA (10 ml)
3. customOn evaporation the resulting oil
4. customwas azeotroped with DCM (×2)
5. customtriturated with Et2O