Sulfamide → 4-Ethanesulfonylpiperazine-1-sulfonamide

HRID 1024943Notes

Reaction equation

HRID 1024943 reaction equation
[CH2:1]([S:3]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)(=[O:5])=[O:4])[CH3:2].[S:12](N)([NH2:15])(=[O:14])=[O:13]>O1CCOCC1>[CH2:1]([S:3]([N:6]1[CH2:7][CH2:8][N:9]([S:12]([NH2:15])(=[O:14])=[O:13])[CH2:10][CH2:11]1)(=[O:5])=[O:4])[CH3:2]

Participants

4

Reactant 2

HCID 82267SulfamideHCID 4152941-(Ethanesulfonyl)piperazine

Product 1

HCID 536283734-Ethanesulfonylpiperazine-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 1-ethanesulfonylpiperazine (1.0 g) in dioxane (10 ml) was added sulfamide (0.51 g). The reaction was then heated at 100° C. for 24 h. The reaction was allowed to cool before being concentrated in vacuo. The residue was stirred in Et2O for 4 h and the mixture filtered to give the product as a white solid. Yield: 1.3 g.

Workup

  1. temperatureto cool
  2. concentrationbefore being concentrated in vacuo
  3. filtrationthe mixture filtered

Sources & evidence

ORD record
ord-13bb671f22b148ce8310912298f315fe
Source dataset
uspto-grants-2014_05
Patent number
US08722883B2

Reaction notes

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