Glycerol → DL-3-n-Butylphthalide

HRID 1025246Notes

Reaction equation

HRID 1025246 reaction equation
O[CH2:2][CH:3]([CH2:5]O)O.[CH2:7]([O:9][C:10]([C:12]1[CH:18]=[CH:17][C:15](O)=[CH:14][CH:13]=1)=[O:11])[CH3:8]>O>[CH2:8]([CH:7]1[C:18]2[C:12](=[CH:13][CH:14]=[CH:15][CH:17]=2)[C:10](=[O:11])[O:9]1)[CH2:2][CH2:3][CH3:5]

Participants

4

Reactant 2

HCID 753GlycerolHCID 8434Ethylparaben

Product 1

HCID 61361DL-3-n-Butylphthalide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
75 °C

Procedure

1000 g of gelatin, 300 g of glycerin, 1300 g of water and 2000 mg of ethylparaben are used. An appropriate amount of water is added into the gelatin, allowing it to absorb water and swell. Glycerin, ethylparaben and residual water are placed into a tank and heated to a temperature of 70 to 80° C., and homogeneously mixed. The swollen gelatin is added with agitation, melted, incubated for 1 to 2 hrs, and kept rest for foams to float up. The floating foams are then scraped, the remainder is filtered through a clean white cloth and kept warm for further use. The viscosity of the resulting gum liquid is generally 2.8 to 3.2 degree.

Workup

  1. customto absorb water and swell
  2. additionhomogeneously mixed
  3. additionThe swollen gelatin is added with agitation
  4. filtrationthe remainder is filtered through a clean white cloth
  5. temperaturekept warm for further use
  6. customis generally 2.8 to 3.2 degree

Sources & evidence

ORD record
ord-b1e985deadcc48cea2ddf04744e03f98
Source dataset
uspto-grants-2014_05
Patent number
US08728518B2

Reaction notes

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