反应详情

(2S,3S)—N-Cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide (4.42 g, 12.5 mmol, Eq: 1.00) was hydrogenated with Pd(OH)2 (20% on carbon, 890 mg, 1.27 mmol, Eq: 0.101) in methanol (50 ml) under a hydrogen pressure of 3.5 bar for 4 h. The catalyst was removed by filtration, and residual solvent was removed under vacuum. The title compound was obtained as a light yellow solid (2.09 g, 96.8%, MS (m/e)=173.2 [M+H+]).

1. customfor 4 h
2. customThe catalyst was removed by filtration, and residual solvent
3. customwas removed under vacuum