3-(azepan-1-yl)-N-benzyl-N-methylpropan-1-amine → 3-(Azepan-1-yl)-N-methylpropan-1-amine

HRID 1025399Notes

Reaction equation

HRID 1025399 reaction equation
[N:1]1([CH2:8][CH2:9][CH2:10][N:11](CC2C=CC=CC=2)[CH3:12])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[N:1]1([CH2:8][CH2:9][CH2:10][NH:11][CH3:12])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 585405163-(azepan-1-yl)-N-benzyl-N-methylpropan-1-amineHCID 178418361HCID 178418361, compound

Product 1

HCID 206007003-(Azepan-1-yl)-N-methylpropan-1-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-(Azepan-1-yl)-N-benzyl-N-methylpropan-1-amine (100 mg) was dissolved in MeOH (20 mL) and to the solution was added 10% Pd/C (50 mg). The reaction mixture was shook under 50 psi hydrogen atmosphere for 2 h. The catalyst was filtered over Cellite and washed with methanol. The filtrated was evaporated to give 3-(azepan-1-yl)-N-methylpropan-1-amine, used without further purification.

Workup

  1. filtrationThe catalyst was filtered over Cellite
  2. washwashed with methanol
  3. customThe filtrated was evaporated

Sources & evidence

ORD record
ord-0cee089173a14ebd94458429875714a0
Source dataset
uspto-grants-2014_05
Patent number
US08729081B2

Reaction notes

Loading…