反应详情

To a degassed solution of tert-butyl 4-(7-fluorobenzofuran-2-yl)-4-hydroxypiperidine-1-carboxylate (0.52 g, 1.55 mmol) in EtOH (9.62 mL) was added 10% Pd—C (0.495 g, 0.465 mmol). Upon completion of addition, the reaction mixture was charged with 55 psi of H2 overnight. After the conclusion of this period, the Pd—C was filtered off through a pad of CELITE®, and the filter cake was rinsed with EtOH. The solvent was removed under reduced pressure to afford Compound 1E as a light yellow solid (0.404 g, 77% yield).

1. additionUpon completion of addition
2. additionthe reaction mixture was charged with 55 psi of H2 overnight
3. filtrationAfter the conclusion of this period, the Pd—C was filtered off through a pad of CELITE®
4. washthe filter cake was rinsed with EtOH
5. customThe solvent was removed under reduced pressure