tert-Butyl 4-(7-fluorobenzofuran-2-yl)-4-hydroxypiperidine-1-carboxylate → tert-Butyl 4-(7-fluoro-2,3-dihydrobenzofuran-2-yl)-4-hydroxypiperidine-1-carboxylate

Participants

Reaction Steps

To a degassed solution of tert-butyl 4-(7-fluorobenzofuran-2-yl)-4-hydroxypiperidine-1-carboxylate (0.52 g, 1.55 mmol) in EtOH (9.62 mL) was added 10% Pd—C (0.495 g, 0.465 mmol). Upon completion of addition, the reaction mixture was charged with 55 psi of H2 overnight. After the conclusion of this period, the Pd—C was filtered off through a pad of CELITE®, and the filter cake was rinsed with EtOH. The solvent was removed under reduced pressure to afford Compound 1E as a light yellow solid (0.404 g, 77% yield).

Provenance & Evidence