2-Chloro-5-propylpyrimidine → 2-(4-(5-Bromo-7-fluoro-2,3-dihydrobenzofuran-2-yl)piperidin-1-yl)-5-propylpyrimidine

HRID 1025499Notes

Reaction equation

HRID 1025499 reaction equation
BrC1C=C(F)C2OC(C3CCNCC3)CC=2C=1.ClC1N=CC(CCC)=CN=1.[Br:28][C:29]1[CH:30]=[C:31]([F:54])[C:32]2[O:36][CH:35]([C:37]3(O)[CH2:42][CH2:41][N:40]([C:43]4[N:48]=[CH:47][C:46]([CH2:49][CH2:50][CH3:51])=[CH:45][N:44]=4)[CH2:39][CH2:38]3)[CH2:34][C:33]=2[CH:53]=1>>[Br:28][C:29]1[CH:30]=[C:31]([F:54])[C:32]2[O:36][CH:35]([CH:37]3[CH2:38][CH2:39][N:40]([C:43]4[N:44]=[CH:45][C:46]([CH2:49][CH2:50][CH3:51])=[CH:47][N:48]=4)[CH2:41][CH2:42]3)[CH2:34][C:33]=2[CH:53]=1

Participants

4

Reactant 3

HCID 27357842-Chloro-5-propylpyrimidineHCID 674657744-(5-Bromo-7-fluoro-2,3-dihydrobenzofuran-2-yl)-1-(5-propylpyrimidin-2-yl)piperidin-4-olHCID 682118944-(5-Bromo-7-fluoro-2,3-dihydrobenzofuran-2-yl)piperidine

Product 1

HCID 682115302-(4-(5-Bromo-7-fluoro-2,3-dihydrobenzofuran-2-yl)piperidin-1-yl)-5-propylpyrimidine

Procedure

Compound 3F was prepared from Compound 3E and 2-chloro-5-propylpyrimidine in a similar manner to the procedure described in Compound 1H, Example 1. LC/MS (m/z)=421 (M+H)+.

Sources & evidence

ORD record
ord-b75c306653414fd8be20ffe15fa02e88
Source dataset
uspto-grants-2014_05
Patent number
US08729084B2

Reaction notes

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