Hydrochloric Acid → HCID 178518098, compound

HRID 1025526Notes

Reaction equation

HRID 1025526 reaction equation
Cl[C:2]1[N:3]=[C:4]([OH:19])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH2:26])=[CH:23][CH:22]=1.Cl>O1CCOCC1>[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH:26][C:2]2[N:3]=[C:4]([OH:19])[C:5]3[N:11]=[C:10]([C:12]4[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=4)[CH:9]=[CH:8][C:6]=3[N:7]=2)=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 673264-FluorobenzylamineHCID 178517814HCID 178517814, compound

Product 1

HCID 178518098HCID 178518098, compoundYield 93.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 2-chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4-ol (730 mg) and 4-fluorobenzyl amine (398 mg) in 1,4-dioxane (20 mL) was heated at 80° C. overnight. 1N HCl (5 ml) was added to the mixture and the resulting solid was filtered to provide 0.9 g of 2-(4-fluorobenzylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4-ol which was characterized by its mass spectrum as follows: MS (m/z) 365 [M+H]+.

Workup

  1. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-1ccae961b71a4a338142cadb48a75a38
Source dataset
uspto-grants-2014_05
Patent number
US08729089B2

Reaction notes

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