Ammonia → HCID 71008280, compound

HRID 1025553Notes

Reaction equation

HRID 1025553 reaction equation
[NH3:1].C[O:3][C:4]([C:6]1[N:7]([CH3:12])[CH:8]=[C:9]([Br:11])[N:10]=1)=O>CO>[Br:11][C:9]1[N:10]=[C:6]([C:4]([NH2:1])=[O:3])[N:7]([CH3:12])[CH:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 53302209methyl 4-bromo-1-methyl-1H-imidazole-2-carboxylate

Product 1

HCID 71008280HCID 71008280, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

To the saturated solution of ammonia in MeOH was added 165 mg of 4-bromo-1-methyl-1H-imidazole-2-carboxylic acid methyl ester and the resulting mixture was stirred at 20° C. for 16 h. The solution was evaporated to give 4-bromo-1-methyl-1H-imidazole-2-carboxylic acid amide (154 mg, yield 100%). LC-MS calcd for C5H6BrN3O (m/e) 202.97, obsd 204 and 206 [M+1]+.

Workup

  1. customThe solution was evaporated

Sources & evidence

ORD record
ord-4d9f8370063647669c10e393382f8540
Source dataset
uspto-grants-2014_05
Patent number
US08729078B2

Reaction notes

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