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HRID1025571

反应详情

EQUATION

反应方程式

HRID 1025571 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)c1ccc(-c2cccc(-n3ncc4cc(C(C)(C)C)ccc4c3=O)c2COC(C)=O)n1C
HCID71008124

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1ccc(-c2cccc(-n3ncc4cc(C(C)(C)C)ccc4c3=O)c2CO)n1C
HCID71008589

未命名化合物

收率 69.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.N
溶剂HCID21705897

未命名化合物

PROCEDURE

实验过程

A mixture of 5-[2-acetoxymethyl-3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester (237 mg, 0.486 mmol) in saturated NH3/MeOH (20 mL) was stirred at room temperature for 48 h. The mixture was evaporated to dryness to give 5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester (150 mg, yield 68%) as a yellow solid. LC-MS calcd for C26H27N3O4 (m/e) 445.20, obsd 913 [2M+Na]+.

WORKUP

后处理

  1. customThe mixture was evaporated to dryness