HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[2-acetoxymethyl-3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester → 5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[2-acetoxymethyl-3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester | HCID 71008124 | — |
| Solvent | Ammonia methanol | HCID 21705897 | — |
| Product | 5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester | HCID 71008589 | 69.3% |
Reaction Steps
A mixture of 5-[2-acetoxymethyl-3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester (237 mg, 0.486 mmol) in saturated NH3/MeOH (20 mL) was stirred at room temperature for 48 h. The mixture was evaporated to dryness to give 5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester (150 mg, yield 68%) as a yellow solid. LC-MS calcd for C26H27N3O4 (m/e) 445.20, obsd 913 [2M+Na]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729078B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-0bb211599c494378aef0018085d7cabb |
| Source note | uspto-grants-2014_05 |