HRID1025574

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID12785854

Ethyl 2-bromo-4-methyl-1,3-oxazole-5-carboxylate

C7H8BrNO3

结构：CC(=O)OCc1c(B2OC(C)(C)C(C)(C)O2)cccc1-n1ncc2cc(C(C)(C)C)ccc2c1=O

HCID58016204

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1oc(-c2cccc(-n3ncc4cc(C(C)(C)C)ccc4c3=O)c2COC(C)=O)nc1C

HCID71008482

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1

催化剂HCID178418228

Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)

C34H28Cl2FeP2Pd

溶剂HCID21886435

1,4-Dioxane--water (1/1)

C4H10O3

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

Under N2, acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl ester (preparation described in intermediate-4, 72 mg, 0.153 mmol), 2-bromo-4-methyl-oxazole-5-carboxylic acid ethyl ester (34 mg, 0.146 mmol), Pd(dppf)Cl2 (36 mg, 0.0438 mmol) and K2CO3 (61 mg, 0.438 mmol) were dissolved in dioxane/H2O (5:1, 6 mL). The reaction mixture was stirred at 100° C. for about 1.5 h. The solvent was removed under reduced pressure, and the residue was purified by silica gel chromatography (petroleum ether/ethyl acetate=2:1) to give 2-[2-acetoxymethyl-3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-phenyl]-4-methyl-oxazole-5-carboxylic acid ethyl ester.

WORKUP

后处理

customThe solvent was removed under reduced pressure
customthe residue was purified by silica gel chromatography (petroleum ether/ethyl acetate=2:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2f3313be377c49d7b3c10aa8861be017
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729078B2
来源说明: uspto-grants-2014_05

反应 SMILES

[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[N:10]([C:16]1[CH:26]=[CH:25][CH:24]=[C:23](B3OC(C)(C)C(C)(C)O3)[C:17]=1[CH2:18][O:19][C:20](=[O:22])[CH3:21])[N:9]=[CH:8]2)([CH3:4])([CH3:3])[CH3:2].[CH2:36]([O:38][C:39]([C:41]1[O:45][C:44](Br)=[N:43][C:42]=1[CH3:47])=[O:40])[CH3:37].C([O-])([O-])=O.[K+].[K+]>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[CH2:36]([O:38][C:39]([C:41]1[O:45][C:44]([C:23]2[CH:24]=[CH:25][CH:26]=[C:16]([N:10]3[N:9]=[CH:8][C:7]4[C:12](=[CH:13][CH:14]=[C:5]([C:1]([CH3:3])([CH3:2])[CH3:4])[CH:6]=4)[C:11]3=[O:15])[C:17]=2[CH2:18][O:19][C:20](=[O:22])[CH3:21])=[N:43][C:42]=1[CH3:47])=[O:40])[CH3:37]