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HRID1025670

反应详情

EQUATION

反应方程式

HRID 1025670 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N1C[C@H](NCc2ccccc2)[C@@H](O)C1
HCID11277777

tert-Butyl (3S,4S)-3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate

C16H24N2O3

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1C[C@H](N)[C@@H](O)C1
HCID10465457

未命名化合物

收率 98.9%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of the intermediate (5.4 g, 18.5 mmol) of step B, Pd(OH)2/C (0.3 g) in MeOH (200 mL) was stirred under hydrogen at 55 psi overnight. The catalyst was filtered off and the filtrate was concentrated to give 3.7 g of the desired product as a solid. MS calculated (M+H)+ 203, found 203.

WORKUP

后处理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated