反应详情

A stirred solution of methyl 2-pyridylacetate (10.0 g, 66.0 mmol), N-bromosuccinimide (13.0 g, 73.0 mmol) and 2,2′-azobisisobutyronitrile (0.50 g, 3.04 mmol) in carbon tetrachloride (120 mL) was irradiated with a sunlamp source for approximately 15 h. After filtration, the filtrate was concentrated in vacuo and the crude residue was purified by flash chromatography on silica gel (gradient elution; 5-10% EtOAc/hexane as eluent) to afford the title compound 5i.

1. filtrationAfter filtration
2. concentrationthe filtrate was concentrated in vacuo
3. customthe crude residue was purified by flash chromatography on silica gel (gradient elution; 5-10% EtOAc/hexane as eluent)