3-Amino-2-methoxypyridine → HCID 67320324, compound

HRID 1025835Notes

Reaction equation

HRID 1025835 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][C:6]=1[C:11](N1C2C(=CC=CC=2)CCC1)=[O:12].[NH2:28][C:29]1[C:30]([O:35][CH3:36])=[N:31][CH:32]=[CH:33][CH:34]=1>>[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[C:6]([C:11]([NH:28][C:29]2[C:30]([O:35][CH3:36])=[N:31][CH:32]=[CH:33][CH:34]=2)=[O:12])=[CH:7][N:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 27374883-Amino-2-methoxypyridineHCID 53311781[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Product 1

HCID 67320324HCID 67320324, compound

Procedure

The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and 3-amino-2-methoxypyridine (commercially available, CAS RN 20265-38-7). The compound was purified by preparative HPLC (Phenomenex Gemini column) using a gradient of acetonitrile:water (10:90 to 95:5). Light brown solid (28%). MS (ESI): m/z=390.040 [M+H]+.

Workup

  1. customThe compound was purified by preparative HPLC (Phenomenex Gemini column)

Sources & evidence

ORD record
ord-22e02cf9c6ad408ea4e0f68693c29cce
Source dataset
uspto-grants-2014_05
Patent number
US08729091B2

Reaction notes

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