2-(Piperidin-1-yl)aniline → 4-(2,5-Dichloro-phenoxy)-N-(2-piperidin-1-yl-phenyl)-nicotinamide

HRID 1025837Notes

Reaction equation

HRID 1025837 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][C:6]=1[C:11](N1C2C(=CC=CC=2)CCC1)=[O:12].[N:28]1([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=2[NH2:40])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[C:6]([C:11]([NH:40][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=2[N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:12])=[CH:7][N:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 4587952-(Piperidin-1-yl)anilineHCID 53311781[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Product 1

HCID 673198574-(2,5-Dichloro-phenoxy)-N-(2-piperidin-1-yl-phenyl)-nicotinamide

Procedure

The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and 2-piperidin-1-yl-phenylamine (commercially available; CAS RN 39643-31-7). White foam (90%). MS (ESI): 442.108 [M+H]+.

Sources & evidence

ORD record
ord-93c6373cec0b4172900c767b0874cffd
Source dataset
uspto-grants-2014_05
Patent number
US08729091B2

Reaction notes

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