Water → Lithium 4-(2,5-dichloro-phenoxy)-6-methyl-nicotinate

Participants

Reaction Steps

To a solution of 420 mg (1.345 mmol) 4-(2,5-dichloro-phenoxy)-6-methyl-nicotinic acid methyl ester in 5 mL dioxane was added 5 mL water and 85 mg (2.018 mmol) lithium hydroxide monohydrate. The reaction mixture was stirred for 2 hours at room temperature and then concentrated under vacuum. The so-obtained light yellow solid was pure enough for the next step without further purification. MS (ESI): m/z=298.004 [M+H]+.

Provenance & Evidence