Water → Lithium 4-(2,5-dichloro-phenoxy)-6-methyl-nicotinate

HRID 1025887Notes

Reaction equation

HRID 1025887 reaction equation
C[O:2][C:3](=[O:20])[C:4]1[C:9]([O:10][C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[Cl:18])=[CH:8][C:7]([CH3:19])=[N:6][CH:5]=1.O.O.[OH-].[Li+:24]>O1CCOCC1>[Cl:18][C:12]1[CH:13]=[CH:14][C:15]([Cl:17])=[CH:16][C:11]=1[O:10][C:9]1[C:4]([C:3]([O-:20])=[O:2])=[CH:5][N:6]=[C:7]([CH3:19])[CH:8]=1.[Li+:24]

Participants

5

Reactant 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 673204514-(2,5-Dichloro-phenoxy)-6-methyl-nicotinic acid methyl ester

Product 1

HCID 67320585Lithium 4-(2,5-dichloro-phenoxy)-6-methyl-nicotinate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 420 mg (1.345 mmol) 4-(2,5-dichloro-phenoxy)-6-methyl-nicotinic acid methyl ester in 5 mL dioxane was added 5 mL water and 85 mg (2.018 mmol) lithium hydroxide monohydrate. The reaction mixture was stirred for 2 hours at room temperature and then concentrated under vacuum. The so-obtained light yellow solid was pure enough for the next step without further purification. MS (ESI): m/z=298.004 [M+H]+.

Workup

  1. concentrationconcentrated under vacuum
  2. customThe so-obtained light yellow solid was pure enough for the next step without further purification

Sources & evidence

ORD record
ord-6275b150ec54488e9cedaad5ed76355e
Source dataset
uspto-grants-2014_05
Patent number
US08729091B2

Reaction notes

Loading…