Hydrochloric Acid → (5-(Trifluoromethyl)-1,2-oxazol-3-yl)methanamine hydrochloride

HRID 1025976Notes

Reaction equation

HRID 1025976 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[O:7][N:6]=[C:5]([CH2:8][NH2:9])[CH:4]=1.[ClH:12]>C(O)C.O1CCOCC1>[ClH:12].[F:11][C:2]([F:1])([F:10])[C:3]1[O:7][N:6]=[C:5]([CH2:8][NH2:9])[CH:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66678829[5-(Trifluoromethyl)-1,2-oxazol-3-yl]methanamine

Product 1

HCID 66687333(5-(Trifluoromethyl)-1,2-oxazol-3-yl)methanamine hydrochloride

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (5-(trifluoromethyl)isoxazol-3-yl)methanamine in 25 ml ethanol was added under cooling 5.12 mL 4M−HCl solution in dioxane over a period of 10 min. The ice-bath was removed and 25 ml diethyl ether was added drop by drop. Precipitation. Filtered off and washed with diethyl ether 83×5 mL). Dried in vacuo at 40° C. to yield 2.65 g of the title compound as a white solid. MS (EI): 166 (M+H)+.

Workup

  1. customThe ice-bath was removed
  2. addition25 ml diethyl ether was added drop by drop
  3. customPrecipitation
  4. filtrationFiltered off
  5. washwashed with diethyl ether 83×5 mL)
  6. customDried in vacuo at 40° C.

Sources & evidence

ORD record
ord-5a1a1df029354abd9e935022c95169a6
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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