反应详情

To a solution of (5-(trifluoromethyl)isoxazol-3-yl)methanamine in 25 ml ethanol was added under cooling 5.12 mL 4M−HCl solution in dioxane over a period of 10 min. The ice-bath was removed and 25 ml diethyl ether was added drop by drop. Precipitation. Filtered off and washed with diethyl ether 83×5 mL). Dried in vacuo at 40° C. to yield 2.65 g of the title compound as a white solid. MS (EI): 166 (M+H)+.

1. customThe ice-bath was removed
2. addition25 ml diethyl ether was added drop by drop
3. customPrecipitation
4. filtrationFiltered off
5. washwashed with diethyl ether 83×5 mL)
6. customDried in vacuo at 40° C.