(4-Chloro-2-fluorophenyl)boronic acid → HCID 66678488, compound

HRID 1025986Notes

Reaction equation

HRID 1025986 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[N:7][C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[C:9](Br)[CH:10]=1)=[O:4].[Cl:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[C:21]([F:28])[CH:20]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:9]2[C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[N:7][CH:6]=[C:5]([CH:10]=2)[C:3]([OH:2])=[O:4])=[C:21]([F:28])[CH:20]=1

Participants

3

Reactant 2

HCID 4193595(4-Chloro-2-fluorophenyl)boronic acidHCID 66686828Methyl 5-bromo-6-(2,2,2-trifluoroethoxy)nicotinate

Product 1

HCID 66678488HCID 66678488, compound

Procedure

The title compound was synthesized in analogy to Examples BI to BJ using 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester (CAN 1211589-51-3) and B-(4-chloro-2-fluorophenyl)-boronic acid, (CAN 160591-91-3) as starting materials; LC-MS (UV peak area/ESI) 98.8%, 348.0061 (M−H)−.

Sources & evidence

ORD record
ord-a1fd52405ba14b8794c2f38c9ecfc4ed
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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