3,4-Difluorobenzeneboronic acid → 5-(3,4-Difluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

HRID 1025990Notes

Reaction equation

HRID 1025990 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:14]([OH:16])=[O:15])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[F:17][C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][C:23]=1[F:24]>>[F:17][C:18]1[CH:19]=[C:20]([C:2]2[C:7]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[N:6][CH:5]=[C:4]([CH:3]=2)[C:14]([OH:16])=[O:15])[CH:21]=[CH:22][C:23]=1[F:24]

Participants

3

Reactant 2

HCID 27343373,4-Difluorobenzeneboronic acidHCID 581925925-Bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 666788705-(3,4-Difluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

Procedure

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1211586-75-2) and B-(3,4-difluorophenyl)-boronic acid, (CAN 168267-41-2) as starting materials.

Sources & evidence

ORD record
ord-e0f78f0825df42269dbc2f9c68071a89
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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