HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluorobenzeneboronic acid → 5-(3,4-Difluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluorobenzeneboronic acid | HCID 2734337 | — |
| Reactant | 5-Bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid | HCID 58192592 | — |
| Product | 5-(3,4-Difluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 66678870 | — |
Reaction Steps
The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1211586-75-2) and B-(3,4-difluorophenyl)-boronic acid, (CAN 168267-41-2) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-e0f78f0825df42269dbc2f9c68071a89 |
| Source note | uspto-grants-2014_05 |