(2-Ethyl-1,3-thiazol-4-yl)methanamine → 5-(4-chloro-phenyl)-N-(2-ethyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 1026007Notes

Reaction equation

HRID 1026007 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20](O)=[O:21])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH2:23]([C:25]1[S:26][CH:27]=[C:28]([CH2:30][NH2:31])[N:29]=1)[CH3:24]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:17])([F:19])[F:18])=[N:12][CH:11]=[C:10]([CH:9]=2)[C:20]([NH:31][CH2:30][C:28]2[N:29]=[C:25]([CH2:23][CH3:24])[S:26][CH:27]=2)=[O:21])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 16494967(2-Ethyl-1,3-thiazol-4-yl)methanamineHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 666784915-(4-chloro-phenyl)-N-(2-ethyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAS Registry No. 1018782-82-5) and 2-ethyl-4-thiazolemethanamine as starting materials; LC-MS (UV peak area/ESI) 98%, 456.074 (M+H)+.

Sources & evidence

ORD record
ord-15e4631cddef4c42bf6658f03e49ab69
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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