HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Ethyl-1,3-thiazol-4-yl)methanamine → 5-(4-chloro-phenyl)-N-(2-ethyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Ethyl-1,3-thiazol-4-yl)methanamine | HCID 16494967 | — |
| Reactant | 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid | HCID 66686971 | — |
| Product | 5-(4-chloro-phenyl)-N-(2-ethyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide | HCID 66678491 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAS Registry No. 1018782-82-5) and 2-ethyl-4-thiazolemethanamine as starting materials; LC-MS (UV peak area/ESI) 98%, 456.074 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-15e4631cddef4c42bf6658f03e49ab69 |
| Source note | uspto-grants-2014_05 |