(2-Ethyl-1,3-thiazol-4-yl)methanamine → 5-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-(2-ethyl-thiazol-4-ylmethyl)-nicotinamide

HRID 1026010Notes

Reaction equation

HRID 1026010 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:19]([OH:21])=O)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][CH:16]2[CH2:18][CH2:17]2)=[CH:4][CH:3]=1.[CH2:22]([C:24]1[S:25][CH:26]=[C:27]([CH2:29][NH2:30])[N:28]=1)[CH3:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([O:14][CH2:15][CH:16]3[CH2:17][CH2:18]3)=[N:12][CH:11]=[C:10]([CH:9]=2)[C:19]([NH:30][CH2:29][C:27]2[N:28]=[C:24]([CH2:22][CH3:23])[S:25][CH:26]=2)=[O:21])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 16494967(2-Ethyl-1,3-thiazol-4-yl)methanamineHCID 666874825-(4-Chlorophenyl)-6-(cyclopropylmethoxy)nicotinic acid

Product 1

HCID 569297585-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-(2-ethyl-thiazol-4-ylmethyl)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-3-pyridinecarboxylic acid (CAS Registry No. 1018782-76-7) and 2-ethyl-4-thiazolemethanamine as starting materials, LC-MS (UV peak area/ESI) 99%, 428.119 (M+H)+.

Sources & evidence

ORD record
ord-84fc03f903a24e25a4b7569f7af2a805
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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