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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1026010Generated: October 31, 2026

(2-Ethyl-1,3-thiazol-4-yl)methanamine → 5-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-(2-ethyl-thiazol-4-ylmethyl)-nicotinamide

https://huagongshe.com/reaction/1026010

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Ethyl-1,3-thiazol-4-yl)methanamineHCID 16494967—
Reactant5-(4-Chlorophenyl)-6-(cyclopropylmethoxy)nicotinic acidHCID 66687482—
Product5-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-(2-ethyl-thiazol-4-ylmethyl)-nicotinamideHCID 56929758—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-3-pyridinecarboxylic acid (CAS Registry No. 1018782-76-7) and 2-ethyl-4-thiazolemethanamine as starting materials, LC-MS (UV peak area/ESI) 99%, 428.119 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729105B2
Source datasetuspto-grants-2014_05
ORD IDord-84fc03f903a24e25a4b7569f7af2a805
Source noteuspto-grants-2014_05