[(1-propyl-1H-pyrazol-3-yl)methyl]amine → 5-(4-chloro-phenyl)-N-(1-propyl-1H-pyrazol-3-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 1026014Notes

Reaction equation

HRID 1026014 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH2:23]([N:26]1[CH:30]=[CH:29][C:28]([CH2:31][NH2:32])=[N:27]1)[CH2:24][CH3:25]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:20])([F:21])[F:22])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:32][CH2:31][C:28]2[CH:29]=[CH:30][N:26]([CH2:23][CH2:24][CH3:25])[N:27]=2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 19576818[(1-propyl-1H-pyrazol-3-yl)methyl]amineHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 569282735-(4-chloro-phenyl)-N-(1-propyl-1H-pyrazol-3-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (CAS Registry No. 1018782-82-5) and 1-propyl-1H-pyrazole-3-methanamine (CAS Registry No. 1006333-47-6) as starting materials, LC-MS (UV peak area/ESI) 96%, 453.29 (M+H)+.

Sources & evidence

ORD record
ord-0d2763b9ae624c36b289ec13c0cfb781
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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