[(1-propyl-1H-pyrazol-3-yl)methyl]amine → 5-(4-chloro-phenyl)-N-(1-propyl-1H-pyrazol-3-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	[(1-propyl-1H-pyrazol-3-yl)methyl]amine	HCID 19576818	—
Reactant	5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid	HCID 66686971	—
Product	5-(4-chloro-phenyl)-N-(1-propyl-1H-pyrazol-3-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide	HCID 56928273	—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (CAS Registry No. 1018782-82-5) and 1-propyl-1H-pyrazole-3-methanamine (CAS Registry No. 1006333-47-6) as starting materials, LC-MS (UV peak area/ESI) 96%, 453.29 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08729105B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-0d2763b9ae624c36b289ec13c0cfb781
Source note	uspto-grants-2014_05