1-(5-Methyl-1,2-oxazol-3-yl)methanamine → 4-(4-chlorophenyl)-N-((5-methylisoxazol-3-yl)methyl)-5-(2,2,2-trifluoro-ethoxy)picolinamide

HRID 1026019Notes

Reaction equation

HRID 1026019 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20]([OH:22])=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH3:23][C:24]1[O:28][N:27]=[C:26]([CH2:29][NH2:30])[CH:25]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:18])([F:19])[F:17])=[CH:12][N:11]=[C:10]([C:20]([NH:30][CH2:29][C:26]3[CH:25]=[C:24]([CH3:23])[O:28][N:27]=3)=[O:22])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27763061-(5-Methyl-1,2-oxazol-3-yl)methanamineHCID 66687043HCID 66687043, compound

Product 1

HCID 569283784-(4-chlorophenyl)-N-((5-methylisoxazol-3-yl)methyl)-5-(2,2,2-trifluoro-ethoxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 5-methyl-3-isoxazolemethanamine (CAS registry No. 154016-48-5) as starting materials; LC-MS (UV peak area/ESI) 100%, 426.0822 (M+H)+.

Sources & evidence

ORD record
ord-a07294b16c1742948896f1c5bdca89a0
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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