HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Methyl-1,2-oxazol-3-yl)methanamine → 4-(4-chlorophenyl)-N-((5-methylisoxazol-3-yl)methyl)-5-(2,2,2-trifluoro-ethoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Methyl-1,2-oxazol-3-yl)methanamine | HCID 2776306 | — |
| Reactant | HCID 66687043 | HCID 66687043 | — |
| Product | 4-(4-chlorophenyl)-N-((5-methylisoxazol-3-yl)methyl)-5-(2,2,2-trifluoro-ethoxy)picolinamide | HCID 56928378 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 5-methyl-3-isoxazolemethanamine (CAS registry No. 154016-48-5) as starting materials; LC-MS (UV peak area/ESI) 100%, 426.0822 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-a07294b16c1742948896f1c5bdca89a0 |
| Source note | uspto-grants-2014_05 |