5-(1-Methylethyl)-3-isoxazolemethanamine → 4-(4-chlorophenyl)-N-((5-isopropylisoxazol-3-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

HRID 1026027Notes

Reaction equation

HRID 1026027 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20]([OH:22])=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH3:23][CH:24]([C:26]1[O:30][N:29]=[C:28]([CH2:31][NH2:32])[CH:27]=1)[CH3:25]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:17])([F:19])[F:18])=[CH:12][N:11]=[C:10]([C:20]([NH:32][CH2:31][C:28]3[CH:27]=[C:26]([CH:24]([CH3:25])[CH3:23])[O:30][N:29]=3)=[O:22])[CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 280651515-(1-Methylethyl)-3-isoxazolemethanamineHCID 66687043HCID 66687043, compound

Product 1

HCID 569284824-(4-chlorophenyl)-N-((5-isopropylisoxazol-3-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 5-(1-methylethyl)-3-isoxazolemethanamine (CAS Registry No. 154016-49-6) as starting materials; LC-MS (UV peak area/ESI) 98.5%, 454.1122 (M+H)+.

Sources & evidence

ORD record
ord-ef4c19e6707d42d4aafa92af31cc3cbc
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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