HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(1-Methylethyl)-3-isoxazolemethanamine → 4-(4-chlorophenyl)-N-((5-isopropylisoxazol-3-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(1-Methylethyl)-3-isoxazolemethanamine | HCID 28065151 | — |
| Reactant | HCID 66687043 | HCID 66687043 | — |
| Product | 4-(4-chlorophenyl)-N-((5-isopropylisoxazol-3-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide | HCID 56928482 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 5-(1-methylethyl)-3-isoxazolemethanamine (CAS Registry No. 154016-49-6) as starting materials; LC-MS (UV peak area/ESI) 98.5%, 454.1122 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-ef4c19e6707d42d4aafa92af31cc3cbc |
| Source note | uspto-grants-2014_05 |