(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → (S)-6-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxamide

HRID 1026029Notes

Reaction equation

HRID 1026029 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[N:10][C:9]=2[O:17][C@@H:18]([CH3:23])[C:19]([F:22])([F:21])[F:20])=[CH:4][CH:3]=1.Cl.[CH3:25][O:26][C:27]1[CH:31]=[C:30]([CH2:32][NH2:33])[O:29][N:28]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([NH:33][CH2:32][C:30]3[O:29][N:28]=[C:27]([O:26][CH3:25])[CH:31]=3)=[O:16])[CH:11]=[N:10][C:9]=2[O:17][C@@H:18]([CH3:23])[C:19]([F:22])([F:21])[F:20])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21292276(3-Methoxyisoxazol-5-yl)methanamine hydrochlorideHCID 66678820(S)-6-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxylic acid

Product 1

HCID 56928484(S)-6-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxamide

Procedure

The title compound was synthesized in analogy to Example 1, using (S)-6-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxylic acid (example AG) and 3-methoxy-5-isoxazolemethanamine hydrochloride as starting materials, 455.1 (M+H)+.

Sources & evidence

ORD record
ord-c732c36053ad4e748bd633462e7c00e9
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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