HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → (S)-6-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Methoxyisoxazol-5-yl)methanamine hydrochloride | HCID 21292276 | — |
| Reactant | (S)-6-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxylic acid | HCID 66678820 | — |
| Product | (S)-6-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxamide | HCID 56928484 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using (S)-6-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxylic acid (example AG) and 3-methoxy-5-isoxazolemethanamine hydrochloride as starting materials, 455.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-c732c36053ad4e748bd633462e7c00e9 |
| Source note | uspto-grants-2014_05 |