5-(1-Methylethyl)-3-isoxazolemethanamine → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (5-isopropyl-isoxazol-3-ylmethyl)-amide

HRID 1026041Notes

Reaction equation

HRID 1026041 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([OH:22])=O)[N:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH3:23][CH:24]([C:26]1[O:30][N:29]=[C:28]([CH2:31][NH2:32])[CH:27]=1)[CH3:25]>>[CH:24]([C:26]1[O:30][N:29]=[C:28]([CH2:31][NH:32][C:20]([C:10]2[N:11]=[N:12][C:13]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH:9]=2)=[O:22])[CH:27]=1)([CH3:25])[CH3:23]

Participants

3

Reactant 2

HCID 280651515-(1-Methylethyl)-3-isoxazolemethanamineHCID 66678582HCID 66678582, compound

Product 1

HCID 569286945-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (5-isopropyl-isoxazol-3-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 41, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (example M) and 5-(1-methylethyl)-3-isoxazolemethanamine (CAS Registry No. 154016-49-6) as starting materials; LC-MS (UV peak area/ESI) 99.1%, 455.2 (M+H)+.

Sources & evidence

ORD record
ord-52e39dbe9f294d84bf10edb9aaab0675
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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