HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(1-Methylethyl)-3-isoxazolemethanamine → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (5-isopropyl-isoxazol-3-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(1-Methylethyl)-3-isoxazolemethanamine | HCID 28065151 | — |
| Reactant | HCID 66678582 | HCID 66678582 | — |
| Product | 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (5-isopropyl-isoxazol-3-ylmethyl)-amide | HCID 56928694 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 41, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (example M) and 5-(1-methylethyl)-3-isoxazolemethanamine (CAS Registry No. 154016-49-6) as starting materials; LC-MS (UV peak area/ESI) 99.1%, 455.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-52e39dbe9f294d84bf10edb9aaab0675 |
| Source note | uspto-grants-2014_05 |