(3-Cyclopropyl-1,2-oxazol-5-yl)methanamine → 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-cyclopropyl-isoxazol-5-ylmethyl)-amide

HRID 1026045Notes

Reaction equation

HRID 1026045 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[CH:4][CH:3]=1.[CH:23]1([C:26]2[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=2)[CH2:25][CH2:24]1>>[CH:23]1([C:26]2[CH:30]=[C:29]([CH2:31][NH:32][C:14]([C:12]3[CH:11]=[CH:10][C:9]([O:17][CH2:18][C:19]([F:20])([F:22])[F:21])=[C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[N:13]=3)=[O:16])[O:28][N:27]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 64156762(3-Cyclopropyl-1,2-oxazol-5-yl)methanamineHCID 666784836-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 569287986-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-cyclopropyl-isoxazol-5-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 41, using 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example AF) and 3-cyclopropyl-5-isoxazolemethanamine (CAN 851434-73-6) as starting materials, LC-MS (UV peak area/ESI) 99.6%, 452.2 (M+H)+.

Sources & evidence

ORD record
ord-03eb760af1c6476c87b8a3ec232b0323
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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