HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Cyclopropyl-1,2-oxazol-5-yl)methanamine → 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-cyclopropyl-isoxazol-5-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Cyclopropyl-1,2-oxazol-5-yl)methanamine | HCID 64156762 | — |
| Reactant | 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 66678483 | — |
| Product | 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-cyclopropyl-isoxazol-5-ylmethyl)-amide | HCID 56928798 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 41, using 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example AF) and 3-cyclopropyl-5-isoxazolemethanamine (CAN 851434-73-6) as starting materials, LC-MS (UV peak area/ESI) 99.6%, 452.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-03eb760af1c6476c87b8a3ec232b0323 |
| Source note | uspto-grants-2014_05 |