6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid → 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-cyclopropyl-oxazol-4-ylmethyl)-amide

HRID 1026050Notes

Reaction equation

HRID 1026050 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)=[CH:4][CH:3]=1.[CH:22]1([C:25]2[O:26][CH:27]=[C:28]([CH2:30][NH2:31])[N:29]=2)[CH2:24][CH2:23]1>>[CH:22]1([C:25]2[O:26][CH:27]=[C:28]([CH2:30][NH:31][C:14]([C:12]3[CH:11]=[CH:10][C:9]([O:17][CH2:18][CH:19]4[CH2:21][CH2:20]4)=[C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[N:13]=3)=[O:16])[N:29]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 666786056-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 66678609(2-Cyclopropyl-1,3-oxazol-4-yl)methanamine

Product 1

HCID 569289056-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-cyclopropyl-oxazol-4-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 41, using 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (example AW) and 2-cyclopropyl-4-oxazolmethanamine (example BH) as starting materials, LC-MS (UV peak area/ESI) 97.6%, 424.0 (M+H)+.

Sources & evidence

ORD record
ord-5eb5e5af9c3c4a2488715a0ba529bc1b
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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