(2-(tert-Butyl)thiazol-4-yl)methanamine → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (2-tert-butyl-thiazol-4-ylmethyl)-amide

HRID 1026058Notes

Reaction equation

HRID 1026058 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20](O)=[O:21])[N:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH3:23][C:24]([C:27]1[S:28][CH:29]=[C:30]([CH2:32][NH2:33])[N:31]=1)([CH3:26])[CH3:25]>>[C:24]([C:27]1[S:28][CH:29]=[C:30]([CH2:32][NH:33][C:20]([C:10]2[N:11]=[N:12][C:13]([O:14][CH2:15][C:16]([F:17])([F:19])[F:18])=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[CH:9]=2)=[O:21])[N:31]=1)([CH3:26])([CH3:23])[CH3:25]

Participants

3

Reactant 2

HCID 16494974(2-(tert-Butyl)thiazol-4-yl)methanamineHCID 66678582HCID 66678582, compound

Product 1

HCID 569290975-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (2-tert-butyl-thiazol-4-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 41 using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (example M) and 2-(1,1-dimethylethyl)-4-thiazolemethanamine (CAS Registry No. 937656-81-0) as starting materials; LC-MS (UV peak area/ESI) 99.1%, 485.2 (M+H)+.

Sources & evidence

ORD record
ord-ce74d54990a94b9ab542c876569abf07
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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