HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-(tert-Butyl)thiazol-4-yl)methanamine → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (2-tert-butyl-thiazol-4-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-(tert-Butyl)thiazol-4-yl)methanamine | HCID 16494974 | — |
| Reactant | HCID 66678582 | HCID 66678582 | — |
| Product | 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (2-tert-butyl-thiazol-4-ylmethyl)-amide | HCID 56929097 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 41 using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (example M) and 2-(1,1-dimethylethyl)-4-thiazolemethanamine (CAS Registry No. 937656-81-0) as starting materials; LC-MS (UV peak area/ESI) 99.1%, 485.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-ce74d54990a94b9ab542c876569abf07 |
| Source note | uspto-grants-2014_05 |