[5-(Trifluoromethyl)-1,2-oxazol-3-yl]methanamine → 5-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-(5-trifluoromethyl-isoxazol-3-ylmethyl)-nicotinamide

HRID 1026059Notes

Reaction equation

HRID 1026059 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:19]([OH:21])=O)[CH:11]=[N:12][C:13]=2[O:14][CH2:15][CH:16]2[CH2:18][CH2:17]2)=[CH:4][CH:3]=1.[F:22][C:23]([F:32])([F:31])[C:24]1[O:28][N:27]=[C:26]([CH2:29][NH2:30])[CH:25]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([O:14][CH2:15][CH:16]3[CH2:17][CH2:18]3)=[N:12][CH:11]=[C:10]([CH:9]=2)[C:19]([NH:30][CH2:29][C:26]2[CH:25]=[C:24]([C:23]([F:32])([F:31])[F:22])[O:28][N:27]=2)=[O:21])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 66678829[5-(Trifluoromethyl)-1,2-oxazol-3-yl]methanamineHCID 666874825-(4-Chlorophenyl)-6-(cyclopropylmethoxy)nicotinic acid

Product 1

HCID 569290985-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-(5-trifluoromethyl-isoxazol-3-ylmethyl)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-3-pyridinecarboxylic acid (CAN 1018782-76-7) and 5-trifluoromethyl-isoxazol-3-methanamine (example BF) as starting materials; LC-MS (UV peak area/ESI) 98%, 452.0975 (M+H)+.

Sources & evidence

ORD record
ord-b5148013b2f0410c83927df7c96b0fd3
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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