HuagongsheHuagongshe Chemistry Print Report · For research reference only
[5-(Trifluoromethyl)-1,2-oxazol-3-yl]methanamine → 5-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-(5-trifluoromethyl-isoxazol-3-ylmethyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [5-(Trifluoromethyl)-1,2-oxazol-3-yl]methanamine | HCID 66678829 | — |
| Reactant | 5-(4-Chlorophenyl)-6-(cyclopropylmethoxy)nicotinic acid | HCID 66687482 | — |
| Product | 5-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-(5-trifluoromethyl-isoxazol-3-ylmethyl)-nicotinamide | HCID 56929098 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-3-pyridinecarboxylic acid (CAN 1018782-76-7) and 5-trifluoromethyl-isoxazol-3-methanamine (example BF) as starting materials; LC-MS (UV peak area/ESI) 98%, 452.0975 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-b5148013b2f0410c83927df7c96b0fd3 |
| Source note | uspto-grants-2014_05 |