(2-Cyclopropyl-1,3-oxazol-4-yl)methanamine → 4-(4-chlorophenyl)-N-((2-cyclopropyloxazol-4-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

HRID 1026063Notes

Reaction equation

HRID 1026063 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20](O)=[O:21])[CH:9]=2)=[CH:4][CH:3]=1.[CH:23]1([C:26]2[O:27][CH:28]=[C:29]([CH2:31][NH2:32])[N:30]=2)[CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:18])([F:19])[F:17])=[CH:12][N:11]=[C:10]([C:20]([NH:32][CH2:31][C:29]3[N:30]=[C:26]([CH:23]4[CH2:25][CH2:24]4)[O:27][CH:28]=3)=[O:21])[CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 66678609(2-Cyclopropyl-1,3-oxazol-4-yl)methanamineHCID 66687043HCID 66687043, compound

Product 1

HCID 569291834-(4-chlorophenyl)-N-((2-cyclopropyloxazol-4-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 4-(4-chlorophenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 2-cyclopropyl-oxazol-4-methanamine (example BH) as starting materials; LC-MS (UV peak area/ESI) 96.5%, 452.0987 (M+H)+.

Sources & evidence

ORD record
ord-bbab9bda33164994ac33ef5a7088e358
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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