HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Cyclopropyl-1,3-oxazol-4-yl)methanamine → 4-(4-chlorophenyl)-N-((2-cyclopropyloxazol-4-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Cyclopropyl-1,3-oxazol-4-yl)methanamine | HCID 66678609 | — |
| Reactant | HCID 66687043 | HCID 66687043 | — |
| Product | 4-(4-chlorophenyl)-N-((2-cyclopropyloxazol-4-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide | HCID 56929183 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1 using 4-(4-chlorophenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 2-cyclopropyl-oxazol-4-methanamine (example BH) as starting materials; LC-MS (UV peak area/ESI) 96.5%, 452.0987 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-bbab9bda33164994ac33ef5a7088e358 |
| Source note | uspto-grants-2014_05 |