(2-Cyclopropylthiazol-4-yl)methanamine → 5-(4-chloro-3-methylphenyl)-N-((2-cyclopropylthiazol-4-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][C:3]=1[CH3:23].[CH:24]1([C:27]2[S:28][CH:29]=[C:30]([CH2:32][NH2:33])[N:31]=2)[CH2:26][CH2:25]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:20])[F:21])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:33][CH2:32][C:30]2[N:31]=[C:27]([CH:24]3[CH2:26][CH2:25]3)[S:28][CH:29]=2)=[O:15])=[CH:4][C:3]=1[CH3:23]Participants
3
Procedure
The title compound was synthesized in analogy to Example 1 using 5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid (example BJ) and 2-cyclopropyl-4-thiazolemethanamine (CAN 1083299-53-9) as starting materials; LC-MS (UV peak area/ESI) 95.4%, 482.09 (M+H)+.
Sources & evidence
- ORD record
- ord-623dd26a80904c55b134df36712e197d
- Source dataset
- uspto-grants-2014_05
- Patent number
- US08729105B2
Reaction notes
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